Buy Sofosbuvir Ledipasvir price India Natco

Sofosbuvir Ledipasvir

Modern developments of pharmaceutical companies have led to the discovery of Ledipasvir-a substance that can affect the development of hepatitis C virus

Where to buy and price Ledipasvir

In relation to Ledipasvir reviews are mostly positive. Negative associated with the price of the drug, because the average patient can not afford to buy a medicine for a full course of treatment.

Price Ladieswear in the composition of the combination drug of Harmony quite high. Manufacturers, speaking about the cost of drugs, do not mention the cost of production, and cite the level of prices for liver transplantation, arguing that the latter method is much more expensive than oral therapy.

One Harvey pill in the US costs just over $ 1,100. The 2-month course will cost $ 63,000., 3-month therapy - $ 95500., and the 24-week rate is $ 189,000.

Prices in Israeli clinics below American. 28 tablets Ladieswear to buy in Israel for $ 30,000. In addition, some dealers provide a refund of the value-added tax of 15%.

Currently, there are other opportunities to purchase this drug, despite the fact that its production is not established in Russia. Ordering Ladieswear online can be prepaid, and without it, which certainly adds confidence in diproportionate dealers.

Very popular drugs-generics Harvey, which are produced by some companies with the permission of the developer. Their popularity is justified by the low price. All of the following analogues can be ordered through the official websites of manufacturers. International delivery takes up to 14 days. And you can buy on the website of the official supplier and get the goods without long delivery expectations, here is a link to the online store:

Consider them in more detail:

Drug Ledihep produced by the Indian company Zudus Heptiza LTD. Its cost, for example, in German pharmacies is 650 euros. While there is a possibility of buying in Russia at the price of 15,000 rubles per package (28 tablets) and 45,000 rubles for a 12-week course.
Natco Pharma LTD offers its generic product called Hepsinat LP. Prices are slightly higher, but not significantly. So, 28 tablets Hepсinat LP available at 19500 rubles. The cost of a 12-week course will be 58500 rubles.
The cost of packaging Ledifos, the manufacturer of which is Hetero-Hhealthcare Ltd, is 18500 rubles, 12-week course-55500 rubles.
Always pay attention to documents confirming the quality of the drug, permits for the implementation of activities for the sale and delivery of medicines, etc.
Description of the drug Ledipasvir

Ledipasvir was developed by the American company Gilead Sciences. Previously, this substance was called GS-5885. The action of this drug is aimed at inhibiting the replication processes of non-structural proteins.

Let's understand in more detail the mechanism of action of Ledipasvir. It is known that the structure of hepatitis C virus (HCV) is quite complex and multifaceted. Advanced forms of HCV are dangerous because with long-term development within the body there are new cells, mutated, which have other antigenic properties.

That is why the immune system of an infected person is not able to cope with them: while antibodies to one type of cells are produced, new ones appear. In this regard, it makes sense to use blockers of those structural elements of the virus that are responsible for replication of the latter. Such an element is NS5A. As a blocker, i.e. the inhibitor, Ledipasvir acts, which prevents further propagation of HCV. 

The peculiarity of the drug Ledipasvir is that it does not act as an independent drug that can cure people from hepatitis C, and until recent years has not been presented in the pharmaceutical market. GS-5885 is mandatory to be used in combination with other drugs that fight viruses. Buy Sofosbuvir Ledipasvir  price India

The most famous and effective is the combination of Ledipasvir with Sofosbuvir. The study of the effectiveness and safety of this combination with the addition of the drug ribavirin, as well as without It for the treatment of 1 genotype of hepatitis C at different stages of the disease were carried out in the framework of 3 clinical studies.

The study involved patients with different baseline data in the amount of about 2000 people. All participants were divided into subgroups based on the degree of fibrosis, previous results of therapy, if any.

According to the results, it became clear that a 12-week course of combination of three drugs leads to a stable virological response in 100% of cases. However, the results of therapy with the" duet " of Ledipasvir with Sofosbuvir, conducted in other subgroups, did not differ much in the degree of effectiveness, their rate was 94-95%. Therefore, Gilead Sciences decided to patent the complex of the two mentioned components without Ribavirin. The trade name of this drug was named.

Studies have also shown that treatment with Ledipasvir in combination with Sofosbuvir practically does not cause side effects. The most common negative consequences of such therapy were headache and fatigue, slight drowsiness. It is noteworthy that in the triple therapy of Harvey with Ribavirin undesirable effects were more frequent.

Features purpose Ladieswear

Before prescribing the drug, the attending physician is obliged to conduct appropriate studies to properly take into account the condition of the patient's body and compare the results of the examination with the indications for use and existing contraindications. Since Ledipasvir is not used as an independent drug, but is combined with other substances, the features of the appointment are associated with the properties of all components in the complex. Describe them.

Preliminary analyses before taking Ladieswear

Complex diagnostics should be carried out without fail. Liver tissue biopsy or elastography aims to determine the structure of the organ and the degree of tissue fibrosis. An alternative method of biopsy and elastography is FibroTest that occurs after mathematical treatment of the important blood parameters (haptoglobin, ALPHA2-macroglobulin, gamma glutamyltransferase, apolipoprotein A1, alanine AST, Alt, and total bilirubin). FibroTest is able to show not only the stage of liver fibrosis, but also the level of activity of the necro-inflammatory process. The data of such testing is easily interpreted by medical specialists all over the world.

The complex diagnostics also includes the following studies:

Biochemical, total, and complete blood count.
Testing to determine the genotype and subgenotype.
Determination of viral load. These quantitative data will be further used to determine the efficacy of the drug.
Quantitative analysis of liver enzymes (AST and ALT) and other liver function tests.
Blood test for tumor markers.
Serological study.
Tests for hormones and vitamins.
Ultrasound examination of organs in the abdomen, as well as consultation of a hepatologist, ophthalmologist.

Many clinics offer comprehensive examination services in the shortest possible time, while having high-quality specialists and high-quality equipment.

Indications for use drugs ledypasvir

Treatment of hepatitis with Ledipasvir and Sofosbuvir is applicable in the following cases:

The presence of hepatitis C virus from the first genotype-the results of the first three trials of the drug.
The presence of 4, 5, 6 genotypes of hepatitis C — according to the results of subsequent studies.
Presence of HCV genotype 1 and 4 with HIV co-infection.
The presence of high viral load.
The age of the patient is more than 18 years, because tests with younger patients have not yet been conducted.

Contraindications to the use of drugs with Ledipasvir

The main contraindications to the use of Ledipasvir in the composition of Harvey are:

The presence of co-infection of hepatitis, i.e. two or more types of viruses.
HIV co-infection, except in cases with HCV genotype 1 and 4.
Individual intolerance to any of the components of the drug.
Encephalopathy, i.e. the presence of any non-inflammatory disease that contributes to the appearance of dystrophic changes in brain tissues, which violates the functions of the latter.
Ascites-dropsy in the abdomen. This disease in most cases is justified by liver cirrhosis.
Carrying the fetus (pregnancy) due to the lack of research on this category of patients, as well as the lactation period. Buy Ledipasvir price from the manufacturer, delivery directly from India without intermediaries. Sofosbuvir Ledipasvir cost

Instruction on the use of Ledipasvir with Sofosbuvir States that the previously conducted antiviral therapy, which did not have an effect, the presence of liver cirrhosis are not contraindications to the use of the drug, and do not serve as a reason for reviewing the dosage of drugs

Restrictions on the use of ledipasvir in the composition Of

Restrictions on the use of the drug:

With tenofovir, elvitegravir, emtricitabine drug of Harmony not assigned.
Also in the category of prohibited drugs for simultaneous use with Ledipasvir and Sofosbuvir include tipranavir, St. John's wort, phenytoin, rosuvastatin, which complicate the absorption of Harvey, thereby affecting the effectiveness of therapy in the direction of deterioration.
The manufacturer's instruction States that during therapy with the drug, conception should be carefully avoided, using reliable contraceptives. Buy Ledipasvir price from the manufacturer, delivery directly from India without intermediaries. Sofosbuvir Ledipasvir cost

The approved dosage of the components of the drug in one tablet is as follows: Ledipasvir in the amount of 90 mg, and Sofosbuvir — 400 mg.magnesium stearate and lactose monohydrate are used as additional ingredients.

The treatment regimen is quite simple: one tablet per day without reference to food intake, but it is not desirable to drink the medicine on an empty stomach. The duration of the course is determined by the doctor. The minimum course is 12 weeks. If necessary, the terms are doubled. However, if there are no noticeable improvements in viral load at 8-12 weeks, the drug is likely to be discontinued due to inefficiency.